Why does MTNR1A rs2119882 association with acne only emerge in night shift workers?

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Description

The melatonin receptor polymorphism shows no effect in the general population but becomes significant specifically in night shift workers. This context-dependent genetic effect suggests complex gene-environment interactions that remain unexplained and could inform personalized occupational health strategies.

Gap type: unexplained_observation Source paper: Polymorphisms in MTNR1A (rs2119882) and CLOCK (rs1801260) genes are associated with facial acne susceptibility in gas station workers. (2025, PloS one, PMID:40705802)

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