What molecular mechanisms link CLOCK rs1801260 polymorphisms to increased acne susceptibility?

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Description

The study demonstrates a strong association between CLOCK gene variants and acne risk but provides no mechanistic explanation for how this circadian rhythm transcription factor influences skin pathology. Understanding this pathway could reveal novel therapeutic targets linking circadian disruption to inflammatory skin conditions.

Gap type: unexplained_observation Source paper: Polymorphisms in MTNR1A (rs2119882) and CLOCK (rs1801260) genes are associated with facial acne susceptibility in gas station workers. (2025, PloS one, PMID:40705802)

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