Which of the 70+ LOAD genetic variants are actually disease-relevant versus statistical associations?

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Description

The abstract indicates that few candidate polymorphisms have been assessed for actual disease relevance, suggesting many GWAS hits may not be functionally meaningful. Distinguishing causal variants from linkage associations is critical for prioritizing research efforts.

Gap type: open_question Source paper: In vivo validation of late-onset Alzheimer’s disease genetic risk factors. (2024, Alzheimer’s & dementia : the journal of the Alzheimer’s Association, PMID:38687251)

Evidence summary

Resolved by hypothesis h-var-08a4d5c07a: Gut Microbiome Remodeling to Prevent Systemic NLRP3 Priming in Neurodegeneration. Score: 0.907. Supporting PMIDs: 33875891, 30610225, 31748742, 27519954, 33741860.

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