What are the functional mechanisms by which LOAD genetic risk variants contribute to disease pathogenesis?

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Composite

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Novelty

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Mechanistic

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Druggability

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Priority

85%

Importance

92%

Tractability

75%

Market price

50%

Description

Over 70 genetic loci are associated with LOAD, but few have been functionally validated to understand how they mechanistically contribute to disease. This knowledge gap prevents translation of genetic discoveries into therapeutic targets.

Gap type: open_question Source paper: In vivo validation of late-onset Alzheimer’s disease genetic risk factors. (2024, Alzheimer’s & dementia : the journal of the Alzheimer’s Association, PMID:38687251)

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