What determines whether protective CD11c+ microglia transition to inflammation-promoting phenotypes under pathological conditions?

neuroinflammation open
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Description

The abstract identifies CD11c+ microglia as protective with enhanced clearance and neurotrophic functions, yet notes they can become inflammation-promoting under chronic pathological conditions. The molecular switches governing this phenotypic transition are unknown, limiting therapeutic targeting strategies.

Gap type: unexplained_observation Source paper: Microglia in Brain Aging and Age-Related Diseases: Friends or Foes? (2025, International journal of molecular sciences, PMID:41373648)

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