What mechanisms link kynurenine pathway activation to ADHD neurotransmitter dysregulation?

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Description

The abstract identifies kynurenine pathway impairment and neurotransmitter dysregulation as key ADHD features, but the mechanistic connection remains unexplained. Understanding this link could reveal new therapeutic targets for neurotransmitter-based ADHD interventions.

Gap type: unexplained_observation Source paper: Metabolomic Markers in Attention-Deficit/Hyperactivity Disorder (ADHD) among Children and Adolescents-A Systematic Review. (2024, International journal of molecular sciences, PMID:38673970)

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