What drives the connection between sleep disturbance and stress-induced kynurenine activation in ADHD?

stress neurobiology open
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Description

The abstract reports both melatonin metabolism disruption and stress-induced kynurenine pathway activation, but their interrelationship is unclear. This connection could explain ADHD’s complex symptom profile and guide integrated treatment approaches.

Gap type: unexplained_observation Source paper: Metabolomic Markers in Attention-Deficit/Hyperactivity Disorder (ADHD) among Children and Adolescents-A Systematic Review. (2024, International journal of molecular sciences, PMID:38673970)

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