How does CR2-Crry selectivity affect therapeutic efficacy versus systemic complement inhibition?

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Description

The targeted C3 inhibitor CR2-Crry shows efficacy, but whether its tissue-specific targeting provides advantages over systemic complement inhibition remains unclear. This knowledge gap is crucial for determining optimal therapeutic strategies and minimizing potential immunosuppressive side effects.

Gap type: open_question Source paper: Inhibition of complement C3 signaling ameliorates locomotor and visual dysfunction in autoimmune inflammatory diseases. (None, None, PMID:37481702)

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