What downstream mechanisms link C3 inhibition to improved motor and visual function in NMO?

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Description

The study shows C3 inhibition reduces complement deposition and improves functional outcomes, but the specific molecular pathways connecting complement inhibition to neurological recovery remain unexplained. Understanding these mechanisms is critical for optimizing therapeutic targeting and predicting treatment responses.

Gap type: unexplained_observation Source paper: Inhibition of complement C3 signaling ameliorates locomotor and visual dysfunction in autoimmune inflammatory diseases. (None, None, PMID:37481702)

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