How does noradrenergic inhibition potentiate neuroinflammation without affecting amyloid pathology?

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Description

Both chemogenetic and pharmacological inhibition of noradrenergic signaling increased neuroinflammation while leaving Aβ pathology unchanged. The mechanistic basis for this selective effect on inflammation versus amyloid accumulation is unclear.

Gap type: unexplained_observation Source paper: Impact of noradrenergic inhibition on neuroinflammation and pathophysiology in mouse models of Alzheimer’s disease. (2024, Journal of neuroinflammation, PMID:39696597)

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