What is the mechanistic relationship between circadian disruption and reduced orexin-A in AD pathogenesis?

circadian neurobiology open
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Description

The study shows both circadian gene dysregulation and reduced orexin-A after sleep deprivation, but the causal directionality and molecular mechanisms linking these phenomena to AD progression are not established. Understanding this relationship is essential for targeting circadian pathways therapeutically.

Gap type: unexplained_observation Source paper: Orexin-A and Circadian Disruption in Alzheimer’s Disease: Implications for Amyloid-Beta Pathology. (2025, Molecular neurobiology, PMID:41335394)

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