Why do DNMT1-UHRF1 inhibitors show preferential cytotoxicity in cancer vs non-transformed cells?

epigenetic therapeutics open
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Description

The abstract reports selective toxicity of AMSA-2 and MPB-7 in UHRF1-high cancer lines versus normal cells but doesn’t explain the underlying mechanism. This selectivity principle could inform therapeutic strategies for neurodegenerative diseases involving aberrant DNA methylation.

Gap type: unexplained_observation Source paper: Disrupting the epigenetic alliance: structural insights and therapeutic strategies targeting DNMT1-UHRF1. (2025, Functional & integrative genomics, PMID:40960568)

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