What molecular mechanisms drive EMEC spatial migration from tumor periphery to center during brain invasion?

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Description

The study identifies that early metastatic epithelial cells shift spatially from peripheral to central tumor regions as invasion progresses, but the mechanistic drivers of this migration pattern are not explained. Understanding this could reveal targetable pathways for preventing brain metastasis progression.

Gap type: unexplained_observation Source paper: Single-cell RNA sequencing and spatial transcriptome reveal potential molecular mechanisms of lung cancer brain metastasis. (2024, International immunopharmacology, PMID:39079345)

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