How do MIF-mediated ligand-receptor interactions functionally regulate EMEC metastatic behavior?

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Market price

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Description

While MIF-(CD74+CXCR4) and MIF-(CD74+CD44) communication between EMEC and immune cells is identified, the functional consequences of these interactions on metastatic progression remain unclear. This mechanistic gap limits therapeutic targeting of these pathways.

Gap type: unexplained_observation Source paper: Single-cell RNA sequencing and spatial transcriptome reveal potential molecular mechanisms of lung cancer brain metastasis. (2024, International immunopharmacology, PMID:39079345)

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