Why does cerebrovascular pathology associate with lower Braak staging in Alzheimer's disease?

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Description

The finding that cerebrovascular changes correlate with lower Braak and Braak stage contradicts expectations that vascular pathology would worsen AD severity. This inverse relationship suggests unknown protective mechanisms or alternative pathological pathways that could inform therapeutic strategies.

Gap type: contradiction Source paper: Aggregate effects of vascular risk factors on cerebrovascular changes in autopsy-confirmed Alzheimer’s disease. (2015, Alzheimer’s & dementia : the journal of the Alzheimer’s Association, PMID:25022538)

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