What mechanisms underlie the aggregate vascular risk effect when individual factors show no association?

cerebrovascular disease open
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Description

Individual vascular risk factors showed no relationship to cerebrovascular changes, yet multiple factors together did associate with pathology. The biological basis for this emergent aggregate effect remains unexplained, limiting targeted intervention development.

Gap type: unexplained_observation Source paper: Aggregate effects of vascular risk factors on cerebrovascular changes in autopsy-confirmed Alzheimer’s disease. (2015, Alzheimer’s & dementia : the journal of the Alzheimer’s Association, PMID:25022538)

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