How do neuroinflammation biomarkers mechanistically relate to neurodegeneration markers in AD progression?

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Description

The abstract mentions both neuroinflammation (GFAP, TSPO-PET) and neurodegeneration (NFL, brain-derived tau) biomarkers provide insights into disease progression, but the mechanistic relationship between these processes remains unclear. This gap limits understanding of disease pathophysiology and biomarker interpretation.

Gap type: unexplained_observation Source paper: Potential diagnostic markers in Alzheimer’s disease: current perspectives and future directions. (2026, Neurodegener Dis Manag, PMID:40911035)

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