How does CHRM1 activation mechanistically regulate BDNF/TrkB signaling in the hippocampus?

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Description

The study shows that cholinergic circuit disruption reduces BDNF/TrkB signaling, suggesting crosstalk between these pathways. However, the molecular mechanisms linking CHRM1 activation to BDNF production and TrkB phosphorylation are not elucidated, limiting therapeutic target development.

Gap type: unexplained_observation Source paper: Exercise-conditioned plasma ameliorates postoperative cognitive dysfunction by activating hippocampal cholinergic circuit and enhancing BDNF/TrkB signaling. (2024, Cell communication and signaling : CCS, PMID:39558340)

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