Why do inherited ASD variants enrich different biological pathways than de novo variants despite converging on shared networks?

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Description

The study shows inherited variants affect cytoskeletal organization and ion transport pathways, distinct from previous de novo variant studies, yet both contribute to common protein networks. This pathway divergence with network convergence lacks mechanistic explanation and could reveal fundamental differences in ASD etiology.

Gap type: unexplained_observation Source paper: Inherited and De Novo Genetic Risk for Autism Impacts Shared Networks. (2019, Cell, PMID:31398340)

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