How do organelle-specific selective autophagy pathways differentially contribute to neuronal survival?

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Description

While the abstract mentions selective recycling of various organelles (mitochondria, ER, ribosomes, etc.), it’s unclear how dysfunction in specific organellar autophagy pathways uniquely impacts neuronal health. This knowledge gap limits precision therapeutic approaches targeting specific autophagy subtypes in neurodegeneration.

Gap type: open_question Source paper: Selective autophagy in cancer: mechanisms, therapeutic implications, and future perspectives. (2024, Molecular cancer, PMID:38262996)

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