Can randomized controlled trials confirm the neuroprotective effects observed in this retrospective cohort?

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Description

The authors explicitly state that further trials are warranted to confirm these outcomes, as retrospective observational data cannot establish causality. Prospective RCTs are essential to validate these promising neuroprotective signals and guide clinical practice.

Gap type: open_question Source paper: Neurodegeneration and Stroke After Semaglutide and Tirzepatide in Patients With Diabetes and Obesity. (2025, JAMA network open, PMID:40663350)

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