How does Aβ-induced p39 S-nitrosylation lead to dendrite retraction and spine loss?

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Description

While the study demonstrates that p39 S-nitrosylation contributes to Aβ-induced synaptic structural changes, the mechanistic pathway from protein modification to morphological alterations remains unclear. This gap limits understanding of how redox modifications translate to synaptic pathology.

Gap type: unexplained_observation Source paper: S-Nitrosylation of p39 promotes its degradation and contributes to synaptic dysfunction induced by β-amyloid peptide. (None, None, PMID:39256547)

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