How does peripheral tumor-induced gut dysbiosis contribute to brain inflammation and behavioral symptoms?

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Description

The authors demonstrate elevated brain pro-inflammatory cytokines alongside altered gut microbiome in tumor-bearing mice, suggesting a gut-brain axis involvement in cancer-related behavioral symptoms. The mechanistic link between microbiome changes and neuroinflammation remains uncharacterized.

Gap type: unexplained_observation Source paper: Mammary tumors alter the fecal bacteriome and permit enteric bacterial translocation. (2022, BMC cancer, PMID:35248004)

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