What molecular mechanisms underlie SLC35A2 deficiency-induced delay in neuronal radial migration?

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Description

The study identifies that Slc35a2 deficiency disrupts corticogenesis by delaying radial migration from the subventricular zone, but the specific molecular pathways mediating this migration defect remain unexplained. Understanding these mechanisms is critical for developing targeted therapies for MOGHE.

Gap type: unexplained_observation Source paper: Mouse models of Slc35a2 brain mosaicism reveal mechanisms of mild malformations of cortical development with oligodendroglial hyperplasia in epilepsy. (2024, Epilepsia, PMID:39460689)

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