How does predifferentiation GenX exposure establish persistent neurotoxic effects in mature neurons?

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Description

GenX exposure before differentiation causes lasting alterations in mature cortical neurons, but the molecular memory mechanisms enabling this developmental programming are unclear. Understanding this could reveal critical windows for PFAS-induced neurodevelopmental damage.

Gap type: unexplained_observation Source paper: Predifferentiation Neurotoxicity of GenX Exposure on hiPSC-Derived Cortical Neurons. (2026, Environ Sci Technol, PMID:41871202)

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