What determines selective C3 versus C1q complement activation at synapses in demyelinating disease?

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Description

The study shows increased C3 but not C1q at synapses during synapse loss, indicating selective alternative complement pathway activation. The molecular mechanisms controlling this pathway specificity at synapses remain unexplained but could inform targeted therapeutic approaches.

Gap type: unexplained_observation Source paper: Targeted Complement Inhibition at Synapses Prevents Microglial Synaptic Engulfment and Synapse Loss in Demyelinating Disease. (None, None, PMID:31883839)

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