Why does MEF2C loss affect neuronal differentiation but spare NSC proliferation and survival?

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Description

The selective impact on differentiation while preserving proliferation and survival suggests MEF2C acts at specific developmental stages. Understanding this temporal specificity could reveal critical windows for therapeutic intervention in neurodevelopmental disorders.

Gap type: unexplained_observation Source paper: Transcription factor MEF2C influences neural stem/progenitor cell differentiation and maturation in vivo. (None, None, PMID:18599437)

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