How does MEF2C dysfunction specifically lead to Rett syndrome-like behavioral phenotypes?

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Description

The conditional knockout produces behavioral deficits reminiscent of Rett syndrome, but the causal link between MEF2C loss, altered neuronal maturation, and specific autism-related behaviors is not mechanistically explained. This connection is critical for understanding autism spectrum disorder pathogenesis.

Gap type: unexplained_observation Source paper: Transcription factor MEF2C influences neural stem/progenitor cell differentiation and maturation in vivo. (None, None, PMID:18599437)

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