What mechanisms link olfactory loss and color vision deficits to synucleinopathy progression?

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Description

Both olfactory dysfunction and abnormal color vision strongly predicted conversion (HR 2.8 and 3.1 respectively), but the pathophysiological connections to alpha-synuclein pathology remain unclear. Elucidating these links could identify early intervention targets.

Gap type: unexplained_observation Source paper: Parkinson risk in idiopathic REM sleep behavior disorder: preparing for neuroprotective trials. (2015, Neurology, PMID:25681454)

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