What is the direct molecular mechanism by which Meis2 regulates Sonic hedgehog signaling in cochlear development?

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Description

The study shows Meis2 knockout produces Shh-like phenotypes and dysregulates Shh-responsive genes, but the direct mechanistic link between Meis2 and Shh pathway regulation remains unexplained. Understanding this mechanism is crucial for comprehending transcriptional control of neural patterning.

Gap type: unexplained_observation Source paper: Analysis of Meis2 knockout mice reveals Sonic hedgehog-mediated patterning of the cochlear duct. (None, None, PMID:39351969)

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