Why do transferred mitochondria cause oxidative damage despite being metabolically active organelles?

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Description

This finding contradicts the prevailing view that mitochondrial transfer is universally beneficial for recipient cells. The paradoxical increase in oxidative stress challenges therapeutic approaches using mitochondrial transplantation for neurodegenerative diseases.

Gap type: contradiction Source paper: Transferred mitochondria accumulate reactive oxygen species leading to recipient cell damage (2021, PNAS, PMID:34285270)

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