What determines the temporal sequence of pluripotency enhancer selection during neuronal reprogramming?

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Description

The study reveals that pluripotency enhancer selection is stepwise with early OSK-dependent and later OS-dependent phases, but the molecular clock governing this timing is unexplained. This knowledge gap limits optimization of reprogramming protocols for neurological disease modeling and therapy.

Gap type: unexplained_observation Source paper: Cooperative Binding of Transcription Factors Orchestrates Reprogramming. (2017, Cell, PMID:28111071)

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