What determines the specificity of LGI1-OPALIN interaction versus other potential LGI1 receptors?

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Description

While OPALIN is identified as an LGI1 receptor, the molecular determinants of this specific interaction and whether LGI1 has additional receptors in different cell types or developmental stages is unclear. This specificity is crucial for understanding LGI1’s broader neurological functions.

Gap type: open_question Source paper: OPALIN is an LGI1 receptor promoting oligodendrocyte differentiation. (2024, Proceedings of the National Academy of Sciences of the United States of America, PMID:39083419)

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