How does OPALIN function as both a paranodal structural protein and an LGI1 signaling receptor?

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Description

OPALIN was previously characterized as a structural component of paranodal loops, but this study reveals it also functions as a signaling receptor for LGI1. The molecular mechanisms enabling this dual functionality and potential conflicts between roles remain unexplored.

Gap type: unexplained_observation Source paper: OPALIN is an LGI1 receptor promoting oligodendrocyte differentiation. (2024, Proceedings of the National Academy of Sciences of the United States of America, PMID:39083419)

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