How do microbiota-interoception-reward interactions differ between under-eating and over-eating phenotypes?

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Description

The authors mention that microbial-brain interactions may occur differently in under- and over-eating phenotypes but don’t explain the mechanistic differences. This knowledge gap limits the development of phenotype-specific therapeutic approaches for eating disorders.

Gap type: open_question Source paper: The microbiome and eating disorders: a new framework at the interface of interoception and reward. (2026, Neuroscience, PMID:41921818)

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