How does triolein's autophagy inhibition reconcile with autophagy's established neuroprotective role in stroke?

neurodegeneration open
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Description

The study shows triolein inhibits autophagy to provide neuroprotection, yet autophagy is widely considered neuroprotective in ischemic stroke by clearing damaged organelles. This contradiction challenges current understanding of autophagy’s role in stroke recovery and optimal therapeutic timing.

Gap type: contradiction Source paper: Triolein alleviates ischemic stroke brain injury by regulating autophagy and inflammation through the AKT/mTOR signaling pathway. (2024, Molecular medicine (Cambridge, Mass.), PMID:39639187)

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