Why does plasma p217+tau fail to distinguish between Initial (A+T-) and Early (A+TMTL+) AD stages?

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Description

The study shows plasma p217+tau concentrations increase across AD biological stages except between Initial and Early stages, suggesting a disconnect between systemic tau phosphorylation and regional brain tau accumulation. Understanding this discordance is critical for optimizing blood-based staging algorithms.

Gap type: unexplained_observation Source paper: Alzheimer’s disease biological PET staging using plasma p217+tau. (2025, Communications medicine, PMID:40016526)

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