What molecular mechanisms underlie DON's effects on dendritic spine density and synaptic transmission?

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Description

The study demonstrates DON reduces dendritic complexity and spine density while impairing excitatory transmission, but the upstream molecular pathways mediating these structural and functional changes are not elucidated. This mechanistic gap limits understanding of DON neurotoxicity and therapeutic development.

Gap type: unexplained_observation Source paper: Memory impairment mediated by deoxynivalenol via the BLA-PrL circuit. (None, None, PMID:40651373)

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