What molecular mechanisms link chronic SARM1 activation to fibroblast chemokine/complement upregulation?

neuroinflammation open
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Description

The study shows endoneurial fibroblasts increase chemokine and complement expression in response to chronic SARM1 activation, but the signaling pathways mediating this non-immune cell response are unknown. Understanding this mechanism could reveal new therapeutic targets for controlling neuroinflammation in peripheral neuropathies.

Gap type: unexplained_observation Source paper: Diverse cell types establish a pathogenic immune environment in peripheral neuropathy. (2025, Journal of neuroinflammation, PMID:40410792)

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