What accounts for the differential sensitivity of biomarker combinations in predicting specific ADNC stages versus presence?

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Description

The study reveals that combined PET/CSF biomarkers can predict specific AD neuropathology stages, while individual biomarkers detect presence but not staging precision. The biological mechanisms underlying this staging sensitivity difference remain unclear.

Gap type: unexplained_observation Source paper: Associations of the A/T/N profiles in PET, CSF, and plasma biomarkers with Alzheimer’s disease neuropathology at autopsy. (2023, Alzheimer’s & dementia : the journal of the Alzheimer’s Association, PMID:37506291)

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