Can causality be established between amyloid levels and tau propagation patterns?

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Description

The authors explicitly note that causality cannot be inferred from their observational study design. Establishing causal relationships is critical for validating amyloid as a therapeutic target for preventing tau spread.

Gap type: open_question Source paper: Association of Distinct Initial β-Amyloid Levels With Tau Pathology Expansion Beyond the Entorhinal Cortex. (2025, Neurology, PMID:40906972)

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