Why can CTE only be diagnosed postmortem when other tauopathies have emerging biomarkers?

neurodegeneration open
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Description

Despite CTE having a distinctive molecular p-tau fibril configuration unlike other tauopathies, no antemortem diagnostic methods exist while other tau diseases are developing fluid and imaging biomarkers. This diagnostic limitation severely hampers clinical management and research progress.

Gap type: open_question Source paper: Chronic traumatic encephalopathy (CTE): criteria for neuropathological diagnosis and relationship to repetitive head impacts. (None, None, PMID:36759368)

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