Which specific adipokines and immune cell populations in adipose tissue are the primary drivers of AD-related neurodegeneration?

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Description

While the abstract mentions that adipokines and AT-resident immune cells mediate the obesity-AD connection, it doesn’t specify which particular factors are most critical. Identifying the key players would enable more precise therapeutic targeting rather than broad anti-inflammatory approaches.

Gap type: open_question Source paper: Obesity-induced chronic low-grade inflammation in adipose tissue: A pathway to Alzheimer’s disease. (2024, Ageing research reviews, PMID:38977081)

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