How do the 15 brain-absorbed YQTL compounds selectively target the 82 identified proteins?

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Description

The study identifies 15 active ingredients reaching the brain and 82 target proteins, but doesn’t explain the molecular binding specificity or selectivity mechanisms. Understanding these interactions is crucial for optimizing therapeutic efficacy and predicting off-target effects.

Gap type: unexplained_observation Source paper: Elucidation of the mechanism of Yiqi Tongluo Granule against cerebral ischemia/reperfusion injury based on a combined strategy of network pharmacology, multi-omics and molecular biology. (None, None, PMID:37393828)

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