Why does YQTL activate multiple seemingly redundant neuroprotective pathways simultaneously?

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Description

The study shows YQTL activates PI3K-Akt, MAPK, and cAMP pathways concurrently, but doesn’t explain whether this represents pathway crosstalk, compensation, or distinct therapeutic mechanisms. This knowledge gap limits understanding of the compound’s systems-level neuroprotective strategy.

Gap type: unexplained_observation Source paper: Elucidation of the mechanism of Yiqi Tongluo Granule against cerebral ischemia/reperfusion injury based on a combined strategy of network pharmacology, multi-omics and molecular biology. (None, None, PMID:37393828)

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