What determines the differential efficiency between full-length and shortened ARRDC1 fusion constructs?

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Description

The abstract reports that sARRDC1 fusion is more effective than full-length ARRDC1 for Cas9 packaging, but the structural basis for this difference is unexplained. This knowledge gap limits rational design of optimized delivery vectors.

Gap type: unexplained_observation Source paper: Engineering ARMMs for improved intracellular delivery of CRISPR-Cas9. (2025, Extracellular vesicle, PMID:40642206)

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