What molecular mechanism drives insulin-induced 4R-tau expression in developmentally immature neurons?

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Description

The study shows insulin can induce 4R-tau in embryonic neurons that normally only express 3R-tau, but the signaling pathway between insulin and tau isoform switching is not elucidated. Understanding this mechanism is crucial since altered 3R/4R ratios are implicated in multiple tauopathies.

Gap type: unexplained_observation Source paper: 4R-tau isoform induction via TDP-43 in neurons in response to insulin: converging signaling pathways with implications for neurodegenerative disease. (None, None, PMID:41444683)

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