What specific molecular mechanisms link gut microbiota changes to blood-brain barrier repair in CIRI?

neuroinflammation open
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Description

The study shows rhubarb reduces Enterobacteriaceae and improves BBB integrity, but the mechanistic pathway connecting gut dysbiosis correction to BBB repair remains unexplained. Understanding this connection is crucial for developing targeted gut-brain therapeutics for stroke.

Gap type: unexplained_observation Source paper: Neuroprotection of rhubarb extract against cerebral ischaemia-reperfusion injury via the gut-brain axis pathway. (2024, Phytomedicine : international journal of phytotherapy and phytopharmacology, PMID:38342016)

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