Which of the 26 identified rhubarb components are responsible for the neuroprotective effects?

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Description

The authors identified 26 active components but did not determine which specific compounds drive the observed neuroprotection. This knowledge gap limits the development of standardized, targeted therapeutics and understanding of structure-activity relationships.

Gap type: open_question Source paper: Neuroprotection of rhubarb extract against cerebral ischaemia-reperfusion injury via the gut-brain axis pathway. (2024, Phytomedicine : international journal of phytotherapy and phytopharmacology, PMID:38342016)

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