How does transient GABA interneuron inhibition produce sustained antidepressant effects beyond the inhibition period?

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Description

The study shows that temporary inhibition of interneurons leads to sustained antidepressant responses, but the mechanisms maintaining these long-lasting effects after inhibition ends are not explained. This gap is critical for understanding treatment durability.

Gap type: unexplained_observation Source paper: Inhibition of GABA interneurons in the mPFC is sufficient and necessary for rapid antidepressant responses. (2021, Molecular psychiatry, PMID:33070149)

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